2. JAK/STAT Signaling Stem Cell/Wnt PI3K/Akt/mTOR Anti-infection
  3. STAT Akt HIV
  4. Scutellarin

Scutellarin  (Synonyms: 野黄芩苷)

目录号: HY-N0751 纯度: 98.56%
COA 产品使用指南

摩尔计算器

Scutellarin 是从黄芩中分离到的黄酮类物质，在 HCC 细胞中，能够下调 STAT3/Girdin/Akt 信号通路，在破骨细胞中，能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。Scutellarin 具有抗 HIV-1IIIB，HIV-1(74V) 和 HIV-1KM018 的活性，EC50 分别为 26 μM，253 μM 和 136 μM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Scutellarin Chemical Structure

Scutellarin Chemical Structure

CAS No. : 27740-01-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥500
In-stock
5 mg ￥297
In-stock
10 mg ￥446
In-stock
25 mg ￥780
In-stock
50 mg ￥1400
In-stock
100 mg ￥1960
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Scutellarin:

Scutellarin 相关抗体

Top Publications Citing Use of Products

    Scutellarin purchased from MCE. Usage Cited in: Thorac Cancer. 2019 Mar;10(3):492-500.  [Abstract]

    A549 cells are treated with scutellarin (SCU) (0, 200, 400, 600 μM) for 24 hours. Western blotting analyses are used to detect the expression of proteins in the STAT3 pathways, cyclin D1, and cyclin E.

    查看 STAT 亚型特异性产品:

    查看所有亚型
    STAT3 STAT5 STAT6 STAT1

    查看 Akt 亚型特异性产品:

    查看所有亚型
    Akt Akt1 Akt2 Akt3

    查看 HIV 亚型特异性产品:

    查看所有亚型
    HIV HIV-1 HIV-2

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.

    IC50 & Target[1]

    STAT3

     

    HIV-1

     

    体外研究
    (In Vitro)

    Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner, and inhibits migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduces STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Furthermore, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling[1]. Scutellarin selectively enhances Akt phosphorylation[2]. Scutellarin is a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. Acutellarin amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia supporting a functional "cross-talk" between the two glial types[3]. Scutellarin can suppress RANKL-mediated osteoclastogenesis, the function of osteoclast bone resorption, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that Scutellarin can inhibit RANKL-mediated MAPK and NF-κB signaling pathway, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Scutellarin 相关抗体:
    体内研究
    (In Vivo)

    Scutellarin (50 mg/kg/day) significantly mitigates the lung and intrahepatic metastasis of HCC tumors in vivo. The numbers of the lung and intrahepatic metastatic tumors in the scutellarin-treated group are significantly less than that in the controls[1]. The rats treated with Scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Scutellarin enhanced eNOS expression compared with SAH rats[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    462.36

    Formula

    C21H18O12
    CAS 号
    性状

    固体

    颜色

    Light yellow to green yellow

    中文名称

    野黄芩苷；野黄芩甙；灯盏花乙素；高黄芩苷；高黄芩甙；印黄芩苷；黃芹素
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 100 mg/mL (216.28 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.1628 mL 10.8141 mL 21.6282 mL
    5 mM 0.4326 mL 2.1628 mL 4.3256 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： 0.5% CMC-Na/saline water

      Solubility: 10 mg/mL (21.63 mM); 悬浊液; 超声助溶

    • 方案 二

      请依序添加每种溶剂： 15% Cremophor EL    85% Saline

      Solubility: 5 mg/mL (10.81 mM); 悬浊液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 98.56%

    COA (195 KB) HNMR (253 KB) RP-HPLC (278 KB) MS (208 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    To establish an orthotopic liver xenograft model, individual mice are anesthetized with isoflurane and a small incision is made in their abdomen. Individual mice are injected with 2×106 SK-Hep1 cells in 30 μL Matrigel into their left lobe of the liver. Twenty-four hours after orthotopic liver implantation, the mice are randomized and injected intraperitoneally with scutellarin (50 mg/kg/day) or vehicle (0.9% NaCl, normal saline) daily for 35 consecutive days (n=10 per group). Subsequently, the mice are sacrificed, and their lungs and livers are excised, fixed in 10% buffered formalin and paraffin-embedded for hematoxylin and eosin staining.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Scutellarin 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1628 mL 10.8141 mL 21.6282 mL 54.0704 mL
    5 mM 0.4326 mL 2.1628 mL 4.3256 mL 10.8141 mL
    10 mM 0.2163 mL 1.0814 mL 2.1628 mL 5.4070 mL
    15 mM 0.1442 mL 0.7209 mL 1.4419 mL 3.6047 mL
    20 mM 0.1081 mL 0.5407 mL 1.0814 mL 2.7035 mL
    25 mM 0.0865 mL 0.4326 mL 0.8651 mL 2.1628 mL
    30 mM 0.0721 mL 0.3605 mL 0.7209 mL 1.8023 mL
    40 mM 0.0541 mL 0.2704 mL 0.5407 mL 1.3518 mL
    50 mM 0.0433 mL 0.2163 mL 0.4326 mL 1.0814 mL
    60 mM 0.0360 mL 0.1802 mL 0.3605 mL 0.9012 mL
    80 mM 0.0270 mL 0.1352 mL 0.2704 mL 0.6759 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.5407 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Scutellarin27740-01-8野黄芩苷野黄芩甙灯盏花乙素高黄芩苷高黄芩甙印黄芩苷黃芹素STATAktHIVPKBProtein kinase BHuman immunodeficiency virusInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Scutellarin
    目录号：
    HY-N0751
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z